(Ph.D.) Department of Life Science, Gwangju Institute of Science and Technology (GIST) (M.S.) Department of Life Science, Gwangju Institute of Science and Technology (GIST)
약력/경력
2012 ~ Present: Assistant and Associate Professor, Department of Integrative Biotechnology, Sungkyunkwan University, Korea
2007 ~ 2012: Postdoctoral fellow, Center for Reproductive Science, University of California San Francisco (UCSF), USA
관심분야
Regulation of meiotic cell cycle: Cell division is a highly regulated process, driven by the action of cyclin-dependent kinases (Cdks) and their regulatory subunits, cyclins. Inappropriate activation of Cdk/cyclin complexes can drive unregulated cell division resulting in cell death or tumor formation. Cdk/cyclin complexes also play essential roles in a variety of cellular processes such as development and differentiation. Our lab is focused on the action of Cdk/cyclin complexes and all pathways that control or are controlled by Cdk/cyclin complexes during female meiosis.
Homologous chromosome segregation and aneuploidy: Reduction of chromosome number during meiosis is essential for producing haploid gametes from diploid parental cells. This reduction is achieved by two successive rounds of chromosome segregation, meiosis I (MI) and meiosis II (MII), after a single round of DNA replication. Although MII resembles mitosis in that sister chromatids separate and segregate to different daughter cells, the pattern of chromosome segregation during MI is unique. During MI, homologous chromosomes pair and then segregate from each other. Defects in this process result in aneuploidy, leading to miscarriages, infertility and genetic disorders such as Down’s syndrome. Therefore, our lab studies the molecular mechanisms that control homologous chromosome segregation during meiosis.
Control of oocyte quality: Mammalian oocytes are arrested at the prophase of the first meiosis. After LH surge, the oocytes resume meiosis. During these processes, the oocytes is subjected to various sources of damage-inducing factors, which may lead to a progressive deterioration of oocyte quality. Thus, the control of oocyte quality is critical to reproductive success and survival of a species; however, the precise mechanisms underlying this process remain elusive. Our lab is interesting in identifying the molecular mechanisms that control oocyte quality and eventually leading to identification of diagnostic markers that are predictive of oocyte quality in a clinical setting.
Chromatin remodeling during fertilization: Fertilization leads to the transformation of two haploid gametes into a totipotent zygote. During this process, highly condensed chromatins are largely reorganized, preparing to initiate the transcription of embryonic genes which are essential for obtaining the pluripotency. Our lab is exploring the mechanisms of the chromatin remodeling upon fertilization and investigating the role of maternal factors in this process.
연구성과
Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR-eIF4F pathway. Susor A, Jansova D, Ce na R, Danylevska A, Anger M, Toralova T, Malik R, Supolikova J, Cook MS, Oh JS, Kubelka M. Nat Commun. 2015 Jan 28;6:6078.
Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5. Kim T, Cui R, Jeon YJ, Lee JH, Lee JH, Sim H, Park JK, Fadda P, Tili E, Nakanishi H, Huh MI, Kim SH, Cho JH, Sung BH, Peng Y, Lee TJ, Luo Z, Sun HL, Wei H, Alder H, Oh JS, Shim KS, Ko SB, Croce CM. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4173-8.
CIP2A modulates cell-cycle progression in human cancer cells by regulating the stability and activity of Plk1. Kim JS, Kim EJ, Oh JS, Park IC, Hwang SG. Cancer Res. 2013 Nov 15;73(22):6667-78.
Greatwall kinase is required for meiotic maturation in porcine oocytes. Li YH, Kang H, Xu YN, Heo YT, Cui XS, Kim NH, Oh JS*.Biol Reprod. 2013 Sep 12;89(3):53
Cdc25A activity is required for the metaphase II arrest in mouse oocytes. Oh JS, Susor A, Schindler K, Schultz RM, Conti M. J Cell Sci. 2013 Mar 1;126(Pt 5):1081-5.