2006-Present Professor, Sungkyunkwan University, Korea
2003-2005 Assistant Professor, Andong National University, Korea
2001-2003 Postdoctral Research Associate, Iowa State University
2013-2014 Visiting Professor, University of Illinois at Urbana Champaign
관심분야
Development of chemical regulators of SNARE-driven membrane fusion, and development of Botox substitutes for cosmetic and therapeutic purposes.
Development of nanoperforators of viral envelope for antivirals (e.g., anti-influenza drugs)
Protein engineering of industrial enzymes for improved stability, solubility and activity
Recombinant protein production technologies (protein expression control, purification, refolding and protein characterization through spectroscopies)
연구성과
Jun-Seob Kim et al. (2016) Fumarate-mediated persistence of Escherichia coli against antibiotics. Antimicrobial Agents and Chemotherapy, 60(4)
Jonghyeok Shin et al. (2015) Display of membrane proteins on the heterologous caveolae carved by caveolin-1 in the Escherichia coli cytoplasm, Enzyme and Microbial Technology, 79-80, 55-62.
Jaeil Shin et al. (2014) Multiple conformations of a single SNAREpin between two nanodisc membranes reveals diverse pre-fusion states. Biochemical Journal, 459, 95?102.
Bong-Kyu Choi et al. (2013) Large α-Synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking. Proc. Natl. Acad. Sci. USA, 110 (10) 4087-4092.
Yoosoo Yang et al. (2013) Polyphenols differentially inhibit degranulation of distinct subsets of vesicles in mast cells by specific interaction with granule type-dependent SNARE complexes. Biochemical Journal, 450 (3), 537-546.
Yoo-Soo Yang et al. (2010) Dissection of SNARE-driven membrane fusion and neuroexocytosis by wedging small hydrophobic molecules into the SNARE zipper, Proc. Natl. Acad. Sci. USA, 107(51) 22145-22150.
Han-Ki Lee et al. (2010) Dynamic Ca2+-dependent stimulation of vesicle fusion by membrane-anchored synaptotagmin1, Science, 328, 760-763.